Table 3.
Results of FatiGO Analysis on Noninfected vs NTHi-Infected Chinchilla MEM cDNA Libraries
| Biological Processa | Level | Genes in Noninfected Library | Noninfected Library, % |
Genes in NTHi-Infected Library | NTHi Infected, % |
|---|---|---|---|---|---|
| Defense response | 3 | SPP1, CRSP7, CD97, LTF, ALOX5AP | 2.23 |
S100A9, CCL4, TNFAIP6, C3, LYZ, IL1RN, S100A8, ANXA1, SAA3P, CLU, BNIP3L, F11R, HP |
14.13 |
| Response to external stimulus |
3 |
GNAI2, SPP1, CD97, CTGF, ALOX5AP |
2.23 |
S100A9, CCL4, TNFAIP6, C3, IL1RN, S100A8, ANXA1, SAA3P, CLU, F11R, MKKS |
11.96 |
| Response to stress | 3 |
POLD3, TTN, HSPE1, CSDA, HMGB2, SEPP1, SPP1, AKR1B1, EIF2S1, ANG, CD97, CTGF, ALOX5AP |
5.8 |
S100A9, CCL4, TNFAIP6,C3, NFE2L2, IL1RN, S100A8, ANXA1, SAA3P, TP53INP1, CLU F11R, EIF2AK2, MAP4K1 |
15.22 |
| Response to biotic stimulus |
3 | HSPE1, IGBP1, HSPA5, LTF | 1.79 |
IFITM2, CCL4, LYZ, NFE2L2, CD53, BNIP3L, EIF2AK2 |
7.61 |
| Immune system process | 3 |
HLA-C, MMP9, THY1, SPP1, IGBP1, ELF1, CD97, LTF |
3.57 |
CCL4, NFKBIA, C3, IL1RN, CD53, CLU, EIF2AK2, BCAP31, MAP4K1 |
9.78 |
Abbreviations: cDNA, complementary DNA; GO, Gene Ontology; MEM, middle ear mucosa; NTHi, nontypeable Haemophilus influenzae infection.
a
The GO terms for the biological processes in column 1 were significantly more commonly represented in the infected library than the noninfected library (P ≤.05).