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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Epilepsia. 2010 Jul;51(Suppl 3):39–42. doi: 10.1111/j.1528-1167.2010.02607.x

Table 1.

Effect of treatments on measures of hippocampal excitability in rats of different developmental stages that underwent rapid kindling

Test Compound Baseline hippocampal excitability Kindling acquisition: stage 1 seizures Kindling acquisition: Total number of stage 4 seizures Effect on Kindling retention Effects on kindled seizures
Topiramate Decreased Reduced Reduced No Yes
Retigabine Yes, P14, 21, 35 Only reduced in P14, not P21 and 35 Blocked at all ages Yes at P14 & 21; No at P35 Effective at all ages
Bumetanide No effect in 21, worked at all paramaters at P11, and somewhat at P14
Ganaxolone, 40 mg/kg Not changed P35 rats only Number of seizures increased; seizure duration increased Number of SZ decreased; SZ duration not changed Yes Not studied
Lamotrigine, 30 mg/kg Decreased, P35 rats only Delayed Delayed/reduced No No
Rapamycin analog, 10 mg/kg q 12 h × 4d Not changed, P 35 rats only Not changed Not changed AD-not changed; SZ at AD attenuated
Levetiracetam, 60 mg/kg Decreased No effect Delayed/reduced Yes Yes