Topiramate |
Decreased |
Reduced |
Reduced |
No |
Yes |
Retigabine |
Yes, P14, 21, 35 |
Only reduced in P14, not P21 and 35 |
Blocked at all ages |
Yes at P14 & 21; No at P35 |
Effective at all ages |
Bumetanide |
No effect in 21, worked at all paramaters at P11, and somewhat at P14 |
Ganaxolone, 40 mg/kg |
Not changed P35 rats only |
Number of seizures increased; seizure duration increased |
Number of SZ decreased; SZ duration not changed |
Yes |
Not studied |
Lamotrigine, 30 mg/kg |
Decreased, P35 rats only |
Delayed |
Delayed/reduced |
No |
No |
Rapamycin analog, 10 mg/kg q 12 h × 4d |
Not changed, P 35 rats only |
Not changed |
Not changed |
AD-not changed; SZ at AD attenuated |
|
Levetiracetam, 60 mg/kg |
Decreased |
No effect |
Delayed/reduced |
Yes |
Yes |