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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: J Neurochem. 2010 Feb 25;113(4):919–929. doi: 10.1111/j.1471-4159.2010.06654.x

Table 1.

The effects of kynurenic acid and saclofen on corticosterone secretion in unstressed rats self-administering saline.

Time (min) −15 0 15 35 55
Vehicle, n = 5 41.5 ± 8.9 62.3 ± 13.8 52.4 ± 16.9 83.9 ± 19.6 66.5 ± 12.6
KYN, n = 5 43.7 ± 13.4 54.4 ± 17.7 64.7 ± 13.1 60.9 ± 11.1 58.9 ± 10.5
Saclofen, n = 5 46.8 ± 16.1 48.5 ± 17.9 147.7 ± 23.7* 100.4 ± 29.2 63.8 ± 14.1

Kynurenic acid (KYN, 1.5 nmol), saclofen (10 pmol), or vehicle were bilaterally microinjected intra-PVN. Vehicle and kynurenic acid had no effects on corticosterone release (one-way ANOVA: F(4,24) = 1.2, and 0.4, respectively, p > 0.05). Saclofen increased corticosterone levels only at 15 min (one-way ANOVA: F(4,24) = 4.2, p < 0.05).

*

, p < 0.05, vs. baseline values at −15 and 0 min (Scheffé).