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. 2010 Jul 19;120(8):2817–2828. doi: 10.1172/JCI42020

Figure 6. RNAi-mediated Sirt3 knockdown adversely affects preimplantation developmental outcomes.

Figure 6

(A) Intracytoplasmic injection of both stealth Sirt3 siRNAs led to decreased blastocyst formation rate in preimplantation embryos. Data are derived from 4 independent experiments. (B) Sirt3 siRNA–induced decrease in blastocyst formation rate was suppressed by treatment with NAC. Data are derived from 6 independent experiments. Statistical assessments were performed by applying Ryan’s multiple-comparison test. *P < 0.05; **P < 0.001.