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. 2010 Jul 26;120(8):2684–2698. doi: 10.1172/JCI42118

Figure 7. p61-Sema3E enhances cancer cell metastatic extravasation.

Figure 7

(A) MDA-MB-435 cancer cells expressing p61 (as in Figure 6) were fluorescently labeled and injected intravenously in nude mice. Two days later, the number of metastatic fluorescent cells was quantified in 4 lungs for each experimental group (at least 10 independent stereomicroscopic fields each) with METAMORPH software. Data are given as the mean of traced cells per field. **P < 0.005. (B) The same engineered MDA-MB-435 cancer cells shown in Figure 6D, plus 2 additional batches of Plexin D1-depleted cells (expressing an alternative shRNA sequence indicated by “#2”; see RT-PCR analysis on top) were fluorescently labeled and injected intravenously in nude mice. The number of fluorescent cells in the lungs was quantified by analyzing 4 mice for each experimental group (at least 10 independent stereomicroscopic fields each) with METAMORPH software. Data are given as mean of traced cells per field ± SD. The y-axis is in logarithmic scale. **P < 0.005.