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. 2010 Jul 26;120(8):2953–2966. doi: 10.1172/JCI42551

Figure 6. VLDL-TG secretion rates in DIO and ob/ob mice.

Figure 6

Adult DIO and ob/ob mice were treated with 10 mg/kg/d, i.p., of AM6545 or vehicle for 7 days. TGSRs were determined under fasting conditions from the plasma TG versus time curve after the injection of Triton WR-1339, as described in Methods. (A) Plasma TG accumulation over time after Triton WR-1339 administration (500 mg/kg, i.p.) (B) AM6545-induced increase in TGSR (μmol/kg/h) in DIO and ob/ob mice. Data are mean ± SEM from 6 mice per group. *P < 0.05 relative to corresponding vehicle value.