Figure 1. IgFc receptors on mast cells are dispensable for antibody-mediated, protective immunity against ticks.

(A) C57BL/6 and (B) C57BL/6-Kit^W-sh/W-sh mice were infested with larval H. longicornis ticks once or twice at an interval of 14 days. The relative tick repletion in each experimental group is shown, in that the value in the first infestation was defined as 100%. Data are shown as mean ± SEM, n = 5 (A); n = 4 (B). (C) BMMCs derived from wild-type mice were adoptively transferred to Kit^W-sh/W-sh mice, and the recipient mice were infested and analyzed as in A. Data are shown as mean ± SEM, n = 3 each. (D) μMT and (E) Fcer1g^–/– C57BL/6 mice were infested with ticks as in A, and the relative tick repletion in each group is shown. Data are shown as mean ± SEM, n = 5 (D); n = 4 (E). (F) BMMCs derived from Fcer1g^–/– mice were adoptively transferred to Kit^W-sh/W-sh mice, and the recipient mice were infested and analyzed as in A. Data are shown as mean ± SEM, n = 3 each. Data shown in A–F are representative of at least 3 repeated experiments. **P < 0.01.