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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Drug Discov Today. 2010 Jan 22;15(7-8):265–271. doi: 10.1016/j.drudis.2010.01.001

Figure 2.

Figure 2

Examples of normal and damaged fluorescently labeled hair cells of the zebrafish lateral line. YO-PRO1 selectively labels hair cell nuclei in (a) normal and (b) neomycin-damaged neuromasts. Hair cell protection can thus be assessed easily during screening. For quantitative hair cell counts, FM1-43FX is used to count (c) normal and (d) neomycin-damaged hair cells. In the undamaged neuromast (c), there are approximately 12 visible hair cells. In the damaged neuromast (d), there are two surviving hair cells (arrows) after treatment with one hour of neomycin. Scale bar in (d) = 10 μM and applies to all panels. Reproduced, with permission from the Association for Research in Otolaryngology, from Ref. [40].[E17]