Table 1. Protective drugs identified by zebrafish lateral line screen of NINDS Custom Collection II for protection against neomycin-induced hair cell death^a.

Protective drug	Known activity
Amsacrine	Topoisomerase 2 poison; used as chemotherapeutic agent. Used clinically in other countries; not yet FDA approved.
Carvedilol	Beta-2 adrenergic blocker; used for treatment of hypertension and heart failure; FDA approved.
Cepharanthine	Plasma membrane stabilizer; used for the treatment of nasal allergy, snake venom hemolysis; possible chemotherapeutic adjunct. Used clinically in other countries; not yet FDA approved.
Drofenine	Acetylcholinesterase inhibitor; used as antispasmodic. Used clinically in other countries; not yet FDA approved.
Hexamethyleneamiloride	Diuretic, Na/H exchange inhibitor. Derivative of amiloride; FDA approved. Diuretic.
Phenoxybenzamine	Alpha-1 adrenergic blocker; used as antihypertensive. FDA approved.
9-amino-1,2,3,4-.tetrahydroacridine (Tacrine)	Anticholinergic; acetylcholinesterase inhibitor, used for treatment of Alzheimer's dementia. FDA approved.

^aModified, with permission from the Association for Research in Otolaryngology, from Ref. [40].