Table 2. Candidate ototoxic drugs identified by zebrafish lateral line screen of NINDS Custom Collection II for drugs that cause hair cell death^a.

Ototoxic drug	Class	Known ototoxicity?
Chloramphenicol	Antibiotic	Rare case reports
Chlortetracycline HCL	Antibiotic	No
Pentamidine isethionate	Antiprotozoal	No
Spermadine	Ornithine decarboxylase inhibitor	No
Tobramycin	Antibiotic	Yes
Propantheline bromide	Anticholinergic	No
Ethacrynic acid	Loop diuretic	Yes
Pomiferin	Antioxidant	No
Chlorophyllide	Antineoplastic, chlorophyll derivative	No
Estradiol valerate	Estrogen	Rare case reports
Neomycin	Antibiotic	Yes
Pentetrazole	CNS/respiratory/circulatory stimulant	Yes, animal studies
Guaiazulene	Antioxidant, color additive agent	No
Rosolic acid	Diagnostic aid	No
Cisplatin	Antineoplastic	Yes
Vincamine	Vasodilator	No
Kanamycin	Antibiotic	Yes
Demeclocycline HCL	Antibiotic	No
Mefloquine	Antiprotozoal	Yes
Candesartan	Angiotensin 1 receptor antagonist	No
Simvastatin	HMGCoA reductase inhib., antihyperlipidemic	No

^aModified, with permission from the Association for Research in Otolaryngology, from Ref. [31].