Table 2.
Somatic Mutations in κ1 VL Domain Framework Regions of Amyloidogenic LCs Grouped by Post-Translational Modifications
| dimerization |
S-cysteinylation |
N-glycosylation |
other |
||||||
|---|---|---|---|---|---|---|---|---|---|
| VL domain | AL-99067 | AL-01039 | AL-96066 | AL-01066 | AL-98002 | AL-02004 | AL-01102 | AL-00131 | AL-01090 |
| FR1 (1–23) | I2V | ||||||||
| Q3E | |||||||||
| V15I | |||||||||
| R18T | |||||||||
| V19I | T19V | ||||||||
| T20Na | |||||||||
| T22A | |||||||||
| FR2 (35–49) | Q38H | ||||||||
| K39R | |||||||||
| K42T | K42E | ||||||||
| K45E | K45N | ||||||||
| L46V | |||||||||
| I48V | |||||||||
| Y49D | Y49F | ||||||||
| FR3 (57–88) | R61S | ||||||||
| S63T | |||||||||
| G66A | |||||||||
| D70Na | |||||||||
| T72I | |||||||||
| T74S | |||||||||
| S76T | S76R | ||||||||
| S77G | S77N | S77N | |||||||
| P80A | |||||||||
| A84G | |||||||||
| Y87H | Y87F | ||||||||
| no. of replacement mutations, n | 3 | 3 | 1 | 3 | 7 | 4 | 4 | 2 | 6 |
| VL germline gene | L15 | L5 | O18/O8 | O18/O8 | O18/O8 | O18/O8 | O18/O8 | O18/O8 | O12/O2 |
a
Gain of an asparagine residue that created an N-glycosylation site.