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. Author manuscript; available in PMC: 2011 Jul 23.
Published in final edited form as: Immunity. 2010 Jul 8;33(1):128–140. doi: 10.1016/j.immuni.2010.06.014

Table 1. Repeated antigen exposure alters expression of multiple gene families in memory CD8+ T cell populations.

Biological functions were assigned to genes with significant changes in transcription in at least one of the four memory CD8+ T cell populations. To reduce the number of genes displayed, only genes with an mRNA increase >2-fold in at least two memory CD8+ T cell populations or an mRNA increase >3-fold in at least one memory CD8+ T cell population are shown. Genes were grouped according to their biological function and put in alphabetical order. Non-significant changes for a comparison are blank.

Gene Alias prim sec tert quart
Transcription
Aff3 −3.43 −5.19 −6.62
Atf6 2.59 3.26 3.52
Camk4 −2.15 −2.17 −2.53
Cep290 3.19 3.00 3.15
Dmrta1 Dmrt4 5.18 6.23 4.10 3.80
Egr1 −1.72 −2.06 −2.66 −2.96
Egr2 −4.35 −4.28 −3.77 −4.50
Ell2 3.55 4.77 5.14 4.49
Eomes 5.54 3.36 3.69 2.61
Ern1 2.79 3.29 4.09
Gtf2ird1 −2.24 −2.07
Hopx 2.96 3.55 2.57 3.15
Id2 6.96 8.08 8.97 10.18
Id3 −2.23 −2.29 −2.95 −3.29
Ikzf2 Helios −3.76 −4.20 −3.30 −4.18
Ikzf3 Aiolos 2.83 2.02 2.48
Itgb3bp 2.67 2.76 3.07 2.30
Lass4 2.79 3.01
Lass6 −2.47 −2.98 −3.77
Lef1 −2.31 −2.72 −3.31
Mdfic 1.87 2.26 3.02 2.88
Myb −2.00 −2.69 −3.09
Myc −2.52 −8.32 −14.23
Nr1d1 2.65 2.50 3.01
Nr1d2 2.40 2.66 2.90
Pcgf2 3.95 4.31 4.76
Pde8a 2.77 2.72 3.48
Prdm1 Blimp-1 4.74 7.19 6.76 6.18
Rora 2.22 3.29 5.65 6.49
Runx1 2.17 2.11
Runx2 3.15 2.98 2.81 2.36
Satb1 −1.53 −2.03 −2.76 −4.11
Scmh1 −2.30 −2.27
Smad3 2.25 2.04 2.07
Smyd1 2.24 2.45
Strm −2.08 −2.34 −2.39
Tbl1x −1.76 −2.31 −2.51 −2.38
Tbx21 T-bet 4.12 4.83 5.59 5.46
Tcf7 TCF-1 −2.43 −3.55
Tef 2.80 3.27
Trip4 2.42 2.32
Zbtb7b 1.84 1.88 2.62 2.08
Zeb2 4.76 8.66 13.64 15.66
Cytokines/chemokines
Ccl3 MIP1-α 3.92 5.84 6.38 8.04
Ccl4 MIP1-β 2.92 3.61 4.86 5.17
Ccl5 RANTES 2.57 2.73 3.25 3.65
Ccl6 3.45
Ccl9 3.58 4.65 6.06
CD163l1 −2.75 −2.84 −2.17 −2.36
Ifng 4.21 5.77 6.21 6.30
Il15 4.25 3.52 5.23 6.70
Il6st −3.69 −5.90 −6.45 −6.76
Ltb −2.78 −2.89
Spred1 −3.25
Tnfsf14 CD258 3.61 3.70 3.27 3.17
Tnfsf8 CD30L −3.26 −4.65
Xcl1 3.97
Cytokine receptors
Bmpr1a 3.03
Ifngr2 −4.73 −4.26 −4.73 −6.35
Il10ra 3.67 5.12 3.21 3.35
Il12rb2 2.71 3.61 4.22 5.65
Il18r1 4.07 4.43 4.88 5.30
Il18rap 6.58 9.22 11.57 13.79
Il1rl1 2.29 2.43
Il2ra CD25 5.26 11.36 11.83 12.40
Il2rb CD122 4.05 3.73 2.16 1.98
Il4ra −1.84 −2.17 −2.18
Il6ra −1.76 −2.08 −2.35
Tnfrsf10b DR5 −2.28 −2.41
Tnfrsf26 −4.45
Cytolytic effector molecules
Gzma 18.02
Gzmb 5.30 14.40 25.43 28.71
Gzmm 2.40 2.79 1.86 1.82
Fasl CD95L 6.95 12.82 11.37 23.36
Prf1 Perforin 2.19 3.22 3.82 3.80
Selectins
Sele CD62E −2.66 −2.24 −2.15
Sell CD62L −4.34 −14.12 −30.59
Chemokine receptors
Ccr2 9.82 12.74 13.65 14.88
Ccr4 −3.13
Ccr5 9.08 11.39 18.44 20.28
Ccr7 −2.19 −4.33 −6.50 −7.00
Ccr9 −2.88 −2.92 −3.79
Cx3cr1 3.14 6.41 9.79 10.59
Cxcr3 6.48 5.25
Cxcr6 2.56 2.63 2.78 3.15
Integrins
Itga1 CD49A 8.17 8.89 10.25 12.70
Itga4 CD49D 2.01 2.38 2.84 2.82
Itgae CD103 −8.00 −6.78 −9.33 −7.65
Itgal CD11A 1.78 2.34 2.45 2.57
Itgam CD11B 3.24 3.62 4.36
Itgax CD11C 10.94 10.48 5.13 3.09
Itgb1 CD29 6.24 5.44 6.20 6.11
Itgb2 CD18 2.24 2.29 2.14
Cell adhesion
Actn1 −4.64 −9.04 −13.15 −14.78
Alcam 5.21 5.39 6.43
Camk2n1 2.34 2.72 2.74 3.15
Cd22 2.41 2.48
Cd44 3.28 2.74 2.20 1.91
L1cam 2.25 2.66 2.93 2.85
Lamc1 2.50 4.04 5.00
Lgals1 2.66 3.30 3.77 4.08
Mtss1 −3.78 −3.57 −3.63 −3.97
Nckap1 2.15 3.00 2.27 2.75
Nrp1 4.03 3.93 4.77 4.78
Pcdh21 1.92 3.09
Pecam1 −3.42 −5.25 −7.30
Pros1 2.90 2.32 2.56
RP23- 2.16 2.40 2.57
Apoptosis regulation
Alox8 1.87 2.09 2.08 2.50
Amigo2 −4.79 −6.34 −6.13 −7.64
Bcl2a1a 4.48 4.46 5.81 6.55
Bcl2a1b 3.06 3.15 4.32 4.76
Bcl2a1c 3.73 3.59 3.53 4.30
Bcl2a1d 4.09 4.20 5.34 6.02
Bcl2l1 2.30 2.28 2.36 1.96
Capn2 2.51 3.24 4.04
Casp1 11.90 11.90 14.16 14.25
Casp4 6.21 4.10 5.48 6.30
Dapk2 2.58 3.87 2.90 4.68
Egln3 −2.25 −2.00
Fgl2 −2.09 −2.72
Hip1 1.97 2.78 3.09 3.26
Igf1r −2.01 −2.11
Lag3 2.15
Map3k5 −2.07 −3.32
Naip2 3.30 3.25 3.70
Nod1 2.03 1.96 2.00 1.87
Rnf216 2.58 4.43 5.39 6.37
Serpinb9 4.46 3.89 5.73
Sgk3 −4.11 −3.92 −5.29
Antigen processing and presentation
Fcgr2b 4.07 9.58 13.80 16.39
H2-Oa −2.87 −3.87 −3.56 −4.20
H2-Q10 2.69 2.64 3.13 3.07
Cell division, cell cycle, mitosis
1190002H23Rik −2.06 −2.05
Anxa1 5.73 11.46 14.50 20.09
Cd2ap −2.24 −2.45
Chpt1 3.05 2.69
Dstn 2.18 2.36
Map3k8 2.05 2.07 2.22
Mapre2 3.56 3.72 4.07 4.13
Plekho1 −3.22 −2.55 −2.52 −2.65
Rassf2 −2.01 −2.63 −3.84
S100a6 7.22 7.29 8.51 10.02
Smc4 −1.86 −1.97 −2.50 −2.53
Spo11 −2.28 −2.37
Killer-cell lectin-like receptors
Klra8 LY49H 2.56 3.15 3.17
Klra9 LY49I 4.68 6.11
Klra10 LY49J 5.23 7.10
Klra14 LY49N 4.12 6.64
Klrb1c NK1.1 6.84 11.43 14.82 15.09
Klrb1f 4.41 4.10
Klrc1 NKG2A 18.58 26.34 24.63 30.20
Klrc2 NKG2C 6.53 9.32 11.04 13.90
Klrc3 NKG2E 3.96 5.87 8.58 10.81
Klrd1 CD94 1.69 2.11
Klre1 NKG2I 3.58 7.02 22.19
Klrg1 KLRG-1 9.09 40.79 42.82 48.93
Klri2 2.45 7.54
Klrk1 NKG2D 4.31 4.58 6.98 8.20
Lipid metabolism
Afp −2.45 −2.04
Crot 2.18 2.47
Elovl6 −2.48 −2.29
Osbpl3 5.58 8.11 9.74 12.08
Prune 2.06 3.06 1.86
Soat2 3.94 3.71 4.11 5.02
Ig-domain or Ig like
B430306N03Rik −2.43 −2.53 −2.87 −2.87
Cd244 2B4 5.03
Cd80 2.93 3.55 4.88
Gp49a 7.01 11.54 7.86 8.59
Lair1 2.54 3.92 2.61 3.28
Lilrb4 4.50 5.95 5.20 5.74
Sema4f 2.20 2.35
Slamf1 SLAM 3.01 3.44
Slamf6 NTB-A −3.12 −5.43
Slamf7 CRACC 5.83 6.83 14.61 17.57
Intracellular signal transduction
Als2cl −2.37 −2.61 −3.24
Dock9 2.87 3.89 4.80 4.58
Garnl4 2.30 2.59 2.80
Rab3ip −2.29 −3.15
Ralgps2 −2.98 −3.50
Rangrf −2.24 −2.10
Rap2a 3.29 2.93 2.71
Rapgef4 −4.48 −6.06 −11.74 −12.49
Rhobtb2 −2.07 −2.20
Rras2 −3.57 −3.17 −3.19
Sos2 2.86 2.74
Tbc1d12 2.62 2.24
Adora2a 2.42 2.93 2.30 2.34
Cmklr1 2.35 2.55
Csprs 3.12
Cysltr2 3.66
F2rl1 −3.29 −5.33
F2rl2 2.34 2.92 3.05
Vipr1 −2.25 −3.01 −3.09
Adcy6 −3.19 −3.24 −3.68 −4.13
Cish 2.37 2.06 2.18
Entpd1 5.59 9.13 8.62 12.57
Gna15 2.19 3.68 3.61
Nsg2 −3.52 −4.25 −4.95
Rgs1 4.45 5.11 3.89 4.14
Rgs10 −4.45 −7.93 −8.05
Snx14 2.04 2.15
Trat1 −6.75 −6.82 −6.00 −7.47
Proteolysis
4930523C11Rik −6.84 −7.86 −5.29 −4.96
Capn11 2.41 −2.61
Cd55 −5.78
Ctla2a 6.74 5.71 4.71 4.83
Ctla2b 3.75 3.20
Ctsd 1.75 1.99 2.09 2.04
Dennd4a 5.65 3.55 3.44 6.00
Dpp4 −2.16 −3.67
Ephx1 −5.87 −7.42 −6.06 −4.74
Fbxl2 2.65 2.91
Gzmk 5.56 7.23 5.08 7.56
Lonrf3 4.20
Mmp25 3.13
Nedd4l −2.06 −2.66 −2.87
Prss12 3.60 3.21 3.74 3.34
Rnf144a −2.17 −2.66 −3.90
Serpina3f 3.75 3.58 2.48 2.41
Serpinb1a 2.62 3.40
Tfrc −4.30 −3.98 −5.83
Usp28 −3.91 −5.76 −6.07 −5.94
Usp48 1.72 1.87 2.22 2.14
Wwp1 2.51 2.41 1.92
Cst7 2.21 2.01 2.59 2.54
Protein kinases
Cpne3 3.01
Dgka −1.61 −2.24 −2.21
Dgkh 2.59 3.52 4.47
Grk5 2.33 2.87
Grk6 −2.04 −2.52
Havcr2 TIM-3 4.17 7.94 10.37
Ikbke −2.08 −2.53 −2.56
Insr −5.27 −6.42
Lrrk1 2.14 2.52 3.06 2.89
Map4k2 −2.03 −2.32 −2.37
Map4k4 −1.68 −1.90 −2.21 −2.02
Mapkapk3 2.20 2.56 2.19 2.40
Mlkl 3.00 3.42
Myo3b 3.39 2.87 2.29 2.66
Pacsin1 −2.08 −3.01 −3.19 −3.15
Pdk1 −2.06 −4.66 −7.86 −8.70
Pfkp 1.79 2.13 2.10 2.40
Pik3ap 2.56 4.17 6.01 6.92
Pip4k2a −2.19 −2.42
Plaur −3.28 −3.27 −3.13 −3.08
Ryk 2.05 2.21 1.96 2.39
Trib2 −2.51 −3.50 −3.74 −3.48
Yes1 5.31 7.01 6.36 5.42
MISCELLANEOUS
4631426J05Rik −3.21 −3.11 −2.12 −2.44
5430427O19Rik 2.92 3.03 5.24 4.28
Abca3 −2.12 −2.07 −2.59 −3.00
Abcb1a 2.34 3.69 3.69 4.13
Ahnak 3.80 4.36 4.11 4.59
Ampd1 −5.88 −5.33 −6.17 −6.21
Anxa2 4.75 6.26 5.24 5.49
Arhgap26 2.24 2.75 3.57 4.33
Arsb 2.38 2.02 2.26
Art2b −3.53 −6.30
As3mt 5.63 7.03 6.20
Atp1a1 −2.03 −2.51
Atp1b1 −9.81 −10.47 −7.96 −8.77
Atp2b1 2.54 2.99 3.46 3.33
Atp2b4 4.42 5.99 7.83 8.37
Atp6v0d2 7.08 12.04 5.17 1.98
Atp8b4 2.03 2.02 2.01 2.35
Atxn1 2.06 2.27 2.01 2.16
BC057170 −2.59 −3.03
Bcl9 −3.36 −3.78 −3.83 −4.81
Bicd1 2.03 1.97 2.10
Bspry 2.37 2.72
C230094A16Rik 2.30 2.54
Capg 4.47 6.37
Cd69 −3.50 −2.94
Chsy1 2.05 2.20 2.24
Cnn3 −2.11 −2.35
Cyp17a1 3.46 4.67
Ddx28 3.27 4.88 5.54
Dntt −2.16 −2.83 −3.25
Dpm1 −2.15 −2.06
Eea1 3.06 3.00 3.16 3.55
Emp1 3.40 4.33
Epb4.1l2 −1.72 −1.90 −3.02 −3.87
Ext1 −3.18 −3.67 −3.72
Faah −2.17 −2.27
Fads1 −2.35 −2.03
Fchsd2 −1.87 −2.67 −2.52
Gabarapl2 2.43 2.41
Galnt3 2.96 3.82 7.17 7.65
Gbp3 3.54 3.07
Gnptab 2.15 2.24 2.88 3.15
Golim4 2.13 2.15 2.67
Gria3 −7.83 −8.90 −5.68 −6.33
Hook1 −2.43 −3.97 −4.61
Idh2 −2.39 −2.31 −2.20
Igfbp4 −4.49 −4.62 −2.87 −3.32
Inadl −2.14 −3.03 −3.69
Kcna2 −2.03 −1.92 −1.88 −2.04
Kcnj8 4.49 5.08 7.68 9.35
Kcnk5 3.25 3.10 3.52
Krtcap2 1.57 2.23 2.18
Lgals3 1.99 3.30 3.34 3.60
Lpin1 1.99 2.78 3.28 4.06
Ly6c1 LY-6C 3.65 3.96 5.39 5.90
Mcoln3 −2.08 −1.82 −2.40
Mpp1 −2.24 −2.10
Mtap7 −2.27 −2.09 −2.61
Myo1f 3.16 3.01 3.52 3.70
Myo5a 1.98 2.53 2.60 3.06
Ncald 2.62 2.63 2.97
Nt5e 6.82 4.87 5.96 5.94
Pdlim4 −2.44 −2.13 −1.74
Plek 9.42 9.11 8.61 9.29
Pole2 −3.15 −2.37
Polk 2.17 2.10 2.17 2.23
Prdx4 2.85 3.31 3.30
Reep5 2.30 2.63 2.90
Rpa2 2.27 2.40 1.83 2.13
S100a10 1.90 2.42 2.52
S100a4 7.59 10.70 12.32 15.07
Samd3 10.99 12.16 6.66 5.88
Scml4 −2.16 −2.05
Sdcbp2 2.23 2.66 2.01 3.13
Sec61g 2.05 2.28
Sfmbt2 −2.51 −2.57 −2.33 −2.28
Shmt2 −2.08 −2.07
Slc25a24 3.24 3.42
Slc4a7 2.94 3.46 3.01 2.99
Slc6a19 −2.36 −2.09 −2.96 −2.81
Slc9a7 4.84 7.74 8.46
Slc9a9 1.61 1.82 2.44 2.69
Snx10 3.28 2.85 3.09 3.73
Srxn1 2.01 2.61
St3gal4 2.00 2.75
St3gal6 2.75 2.98 2.50 2.69
St6gal1 −6.17 −9.06 −8.56 −8.93
St8sia1 −4.73 −5.89 −4.15 −3.77
Sytl2 5.45 7.46 5.01 5.62
Sytl3 3.53 3.80
Tox −4.18 −3.89 −3.40
Xdh 1.83 2.36 2.57
Xylt1 2.49 2.09 2.11