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. Author manuscript; available in PMC: 2010 Jul 29.
Published in final edited form as: Nat Genet. 2008 May;40(5):499–507. doi: 10.1038/ng.127

Table 1.

Gene sets associated with human ES cell identity.

Group Gene Set No. of Genes Source Reference

ES expressed ES exp1 380 Overexpressed in hES cells according to 5 or more out of 20 profiling studies Assou et al. 2006
ES exp2 40 Overexpressed in hES cells according to a meta-analysis of 8 profiling studies Assou et al. 2006

NOS targets Nanog targets 988 ChIP-array of Nanog in hES cells, activated genes only Boyer et al. 2005
Oct4 targets 290 ChIP-array of Oct4 in hES cells, activated genes only Boyer et al. 2005
Sox2 targets 734 ChIP-array of Sox2 in hES cells, activated genes only Boyer et al. 2005
NOS targets 179 Overlap of above three sets Boyer et al. 2005
NOS TFs 37 Transcription regulators in NOS targets set

Polycomb targets Suz12 targets 1040 ChIP-array of Suz12 in hES cells Lee et al. 2006
Eed targets 1066 ChIP-array of Eed in hES cells Lee et al. 2006
H3K27 bound 1121 ChIP-array of trimethlyated H3K27 in hES cells Lee et al. 2006
PRC2 targets 654 Overlap of 3 above sets Lee et al. 2006

Myc targets Myc targets1 230 ChIP array of c-Myc in cultured cell lines, focusing on E-box containing genes - high affinity bound subset. Fernandez et al. 2003
Myc targets2 775 ChIP array of c-Myc and of Max in a Bukitt’s Lymphoma cell line, overlap set. Li et al. 2003