Table 1.

MBD-mediated repression of CD44, Cyclin D2, GLIPR1 and PTEN

Repression (%)		Gal4-linked promoter Gal4BD-TRDs			methylated promoter full length proteins					unmethylated promoter full length proteins
		MBD1	MBD2	MeCP2	MBD1v1	MBD1v3	MBD2a	MBD2b	MeCP2	MBD1v1	MBD1v3
CD44	MCF-7	55	-	20	85	5	-	-	45	75	-
	DU145	75	-	55	80	25	-	-	10	75	25
	LNCaP	30	-	-	35	-	-	-	-	70	20
Cyclin D2	MCF-7	65	50	65	90	45	50	45	90	75	50
	DU145	30	-	15	65	30	5	-	50	20	-
	LNCaP	15	25	20	45	50	40	40	65	30	-
GLIPR	MCF-7	20	-	20	50	10	-	-	80	40	-
	DU145	85	45	85	35	-	60	45	65	50	-
	LNCaP	20	-	-	20	25	-	-	-	20	-
PTEN	MCF-7	30	-	15	95	10	45	20	75	75	25
	DU145	80	-	85	75	-	-	-	-	50	25
	LNCaP	20	10	20	30	20	45	35	55	65	-

-, no repression