Table 3.

Univariate and multivariate analysis of factors associated with OR and PFS

UNIVARIATE ANALYSIS
Variables	OR		PFS
	HR (95% CI)	p-value	HR (95%CI)	p-value
Treatment Group
CD3+	0.80 (0.20-3.25)	0.70	0.94 (0.45-1.94)	0.91
CD4+	1.31 (0.32-1.49)	0.36	0.74 (0.35-1.58)	0.41
CD8+	0.86 (0.22-3.58)	0.74	0.84 (0.45-1.72)	0.62
CD56+	7.75 (1.13-42.6)	0.012	2.70 (1.25-5.88)	0.005
CD68+	1.25 (0.79-7.72)	0.55	1.16 (0.55-2.46)	0.69
Foxp3+	0.54 (0.20-3.50)	0.98	0.89 (0.43-1.83)	0.81
K-ras status
WT vs MT	12.81 (2.15-7.7)	0.008	4.36 (1.77-10.7)	0.0007
Control Group
CD3+	0.91 (0.41-4.11)	0.63	0.84 (0.38-3.98)	0.74
CD4+	1.51 (0.61-2.74)	0.54	0.94 (0.52-2.98)	0.52
CD8+	1.32 (0.59-2.42)	0.31	1.20 (0.59-2.31)	0.76
CD56+	1.21 (0.74-2.07)	0.29	1.11 (0.81-1.56)	0.14
CD68+	0.84 (0.58-2.11)	0.36	0.87 (0.44-3.52)	0.27
Foxp3+	0.66 (0.34-1.92)	0.68	0.71 (0.88-1.56)	0.13
MULTIVARIATE ANALYSIS
Variables	OR		PFS
	HR (95% CI)	p-value	HR (95%CI)	p-value
CD56
Negative	1		1
Positive	7.05	0.04	2.62	0.0019
	(1.49-45.76)		(1.14-6.00)
K-ras
Mutated	1		1
Wild Type	11.7	0.013	4.74	0.001
	(1.77-8.33)		(1.8-12.3)

Abbreviations: CI: Confident interval, MT: mutated, WT: wild type, OR: overall response rate, PFS: Progression-free survival