Table 2.
Effect of ONO-AE1-259-01 on Physiologic Parameters
| Parameter | Vehicle | 0.5 nmol | 1 nmol | 2 nmol |
|---|---|---|---|---|
| Pre-ischemia | ||||
| pH | 7.31 ± 0.02 | 7.28 ± 0.47 | 7.30 ± 0.46 | 7.25 ± 0.23 |
| PaCO2 | 43.2 ± 1.8 | 44.4 ± 2.0 | 45.2 ± 1.6 | 43.0 ± 1.3 |
| PaO2 | 133 ± 5 | 139 ± 5 | 130 ± 8 | 134 ± 9 |
| MABP | 78.6 ± 3.9 | 75.6 ± 1.7 | 77.4 ± 2.8 | 72.8 ± 2.5 |
| Ischemia | ||||
| pH | 7.28 ± 0.02 | 7.29 ± 0.64 | 7.26 ± 0.03 | 7.33 ± 0.02 |
| PaCO2 | 44.0 ± 1.8 | 43.2 ± 1.5 | 45.6 ± 2.6 | 43.16 ± 1.6 |
| PaO2 | 129 ± 5 | 133 ± 4 | 124 ± 6 | 133 ± 5 |
| MABP | 74.4 ± 1.7 | 76.6 ± 2.5 | 74.4 ± 1.8 | 74.8 ± 1.7 |
| Reperfusion | ||||
| pH | 7.26 ± 0.03 | 7.28 ± 0.05 | 7.29 ± 0.40 | 7.28 ± 0.25 |
| PaCO2 | 43.0 ± 1.8 | 45.8 ± 1.4 | 47.2 ± 1.3 | 44.8 ± 2.7 |
| PaO2 | 135 ± 9 | 129 ± 6 | 126 ± 7 | 138 ± 9 |
| MABP | 74.6 ± 1.3 | 73.8 ± 1.7 | 76.0 ± 1.6 | 74.0 ± 1.6 |
Measurements were made in arterial blood samples obtained via femoral catheter (n = 5/group).