Table 1. SNPs that show suggestive association with increase risk of pancreatic cancer in Japanese population.
| CHR* | SNP | Position* | Risk allele | RAF | Allelic | Dominant | Recessive | P min | Gene | Relativeloc* | ||||||||||
| Case | Control | P-value | OR | L95 | U95 | P-value | OR | L95 | U95 | P-value | OR | L95 | U95 | |||||||
| 6 | rs9502893 | 1285189 | G | 0.411 | 0.351 | 3.30E-07 | 1.29 | 1.17 | 1.43 | 2.97E-05 | 1.36 | 1.18 | 1.57 | 2.18E-05 | 1.50 | 1.24 | 1.80 | 3.30E-07 | FOXQ1 | 25196 |
| 12 | rs708224 | 32327676 | A | 0.718 | 0.656 | 3.30E-07 | 1.32 | 1.19 | 1.47 | 8.54E-07 | 1.42 | 1.23 | 1.63 | 2.09E-03 | 1.46 | 1.15 | 1.86 | 3.30E-07 | BICD1 | 0 |
| 7 | rs6464375 | 153256776 | A | 0.116 | 0.103 | 1.15E-01 | 1.13 | 0.97 | 1.32 | 7.36E-01 | 1.03 | 0.87 | 1.22 | 4.41E-07 | 3.73 | 2.24 | 6.21 | 4.41E-07 | DPP6 | 0 |
| 7 | rs7779540 | 153253595 | A | 0.116 | 0.103 | 1.08E-01 | 1.14 | 0.97 | 1.33 | 7.12E-01 | 1.03 | 0.87 | 1.23 | 4.58E-07 | 3.72 | 2.23 | 6.20 | 4.58E-07 | DPP6 | 0 |
| 7 | rs6973850 | 153269181 | A | 0.116 | 0.106 | 2.23E-01 | 1.10 | 0.94 | 1.29 | 9.76E-01 | 1.00 | 0.84 | 1.18 | 6.27E-07 | 3.64 | 2.19 | 6.04 | 6.27E-07 | DPP6 | 0 |
| 6 | rs11242679 | 1282311 | A | 0.366 | 0.311 | 2.40E-06 | 1.28 | 1.15 | 1.42 | 1.15E-05 | 1.37 | 1.19 | 1.58 | 2.07E-03 | 1.39 | 1.13 | 1.71 | 2.40E-06 | FOXQ1 | 22318 |
| 6 | rs7750826 | 1281867 | G | 0.365 | 0.311 | 2.57E-06 | 1.28 | 1.15 | 1.41 | 1.30E-05 | 1.37 | 1.19 | 1.57 | 1.98E-03 | 1.39 | 1.13 | 1.71 | 2.57E-06 | FOXQ1 | 21874 |
| 7 | rs10487687 | 153271407 | A | 0.150 | 0.136 | 8.99E-02 | 1.13 | 0.98 | 1.30 | 6.76E-01 | 1.03 | 0.88 | 1.21 | 3.35E-06 | 2.66 | 1.76 | 4.02 | 3.35E-06 | DPP6 | 0 |
| 6 | rs11242674 | 1252846 | A | 0.355 | 0.301 | 3.46E-06 | 1.28 | 1.15 | 1.41 | 9.64E-06 | 1.37 | 1.19 | 1.58 | 4.59E-03 | 1.37 | 1.10 | 1.69 | 3.46E-06 | FOXQ1 | −4829 |
| 2 | rs6711606 | 101288602 | A | 0.135 | 0.116 | 1.27E-02 | 1.20 | 1.04 | 1.39 | 1.86E-01 | 1.12 | 0.95 | 1.32 | 4.02E-06 | 2.81 | 1.81 | 4.37 | 4.02E-06 | RNF149 | 0 |
| 8 | rs10088262 | 124834883 | A | 0.374 | 0.341 | 3.42E-03 | 1.16 | 1.05 | 1.28 | 4.30E-06 | 1.40 | 1.21 | 1.61 | 3.98E-01 | 0.91 | 0.74 | 1.13 | 4.30E-06 | FAM91A1 | −15180 |
| 8 | rs7832232 | 38588460 | A | 0.483 | 0.454 | 1.43E-02 | 1.13 | 1.03 | 1.25 | 7.63E-01 | 0.98 | 0.84 | 1.14 | 5.10E-06 | 1.45 | 1.24 | 1.71 | 5.10E-06 | RNF5P1 | −10528 |
| 2 | rs6736997 | 235279936 | A | 0.372 | 0.328 | 2.95E-04 | 1.20 | 1.09 | 1.33 | 4.96E-02 | 1.15 | 1.00 | 1.33 | 5.85E-06 | 1.57 | 1.29 | 1.91 | 5.85E-06 | ARL4C | −209504 |
| 17 | rs225190 | 27901771 | G | 0.410 | 0.360 | 5.99E-06 | 1.26 | 1.14 | 1.39 | 1.92E-04 | 1.32 | 1.14 | 1.52 | 2.37E-04 | 1.43 | 1.18 | 1.72 | 5.99E-06 | MYO1D | 0 |
| 2 | rs4663158 | 235263691 | A | 0.397 | 0.352 | 1.39E-04 | 1.21 | 1.10 | 1.34 | 2.89E-02 | 1.17 | 1.02 | 1.35 | 6.91E-06 | 1.53 | 1.27 | 1.85 | 6.91E-06 | ARL4C | −193259 |
| 13 | rs2039553 | 79197723 | A | 0.291 | 0.268 | 1.32E-02 | 1.15 | 1.03 | 1.28 | 4.39E-01 | 1.06 | 0.92 | 1.21 | 7.01E-06 | 1.73 | 1.36 | 2.19 | 7.01E-06 | NDFIP2 | 171501 |
| 2 | rs1427593 | 137271694 | A | 0.110 | 0.080 | 1.55E-05 | 1.42 | 1.21 | 1.66 | 7.10E-06 | 1.49 | 1.25 | 1.77 | 4.30E-01 | 1.31 | 0.67 | 2.58 | 7.10E-06 | THSD7B | −193238 |
| 6 | rs3016539 | 162156065 | A | 0.903 | 0.871 | 1.67E-05 | 1.42 | 1.21 | 1.67 | 7.28E-06 | 1.50 | 1.26 | 1.79 | 2.90E-01 | 1.36 | 0.77 | 2.43 | 7.28E-06 | PARK2 | 0 |
| 2 | rs12615966 | 104745389 | A | 0.112 | 0.097 | 1.40E-02 | 1.22 | 1.04 | 1.42 | 1.59E-01 | 1.13 | 0.95 | 1.35 | 7.44E-06 | 3.15 | 1.91 | 5.21 | 7.44E-06 | LOC284998 | −6744 |
| 17 | rs2257205 | 53803296 | A | 0.378 | 0.327 | 1.58E-05 | 1.25 | 1.13 | 1.38 | 7.74E-06 | 1.38 | 1.20 | 1.59 | 2.97E-02 | 1.25 | 1.02 | 1.53 | 7.74E-06 | RNF43 | 0 |
| 5 | rs6879627 | 2162901 | G | 0.575 | 0.522 | 8.12E-06 | 1.25 | 1.14 | 1.39 | 4.66E-04 | 1.31 | 1.12 | 1.52 | 1.57E-04 | 1.42 | 1.18 | 1.69 | 8.12E-06 | LOC731559 | 225138 |
| 17 | rs4924935 | 18694595 | G | 0.269 | 0.228 | 8.80E-05 | 1.25 | 1.12 | 1.40 | 8.15E-06 | 1.37 | 1.19 | 1.58 | 5.06E-01 | 1.11 | 0.82 | 1.48 | 8.15E-06 | PRPSAP2 | (7622 |
| 17 | rs1737947 | 18772157 | G | 0.252 | 0.212 | 3.88E-05 | 1.27 | 1.13 | 1.43 | 8.49E-06 | 1.37 | 1.19 | 1.58 | 2.89E-01 | 1.19 | 0.87 | 1.62 | 8.49E-06 | PRPSAP2 | 0 |
| 13 | rs1886449 | 72830115 | A | 0.424 | 0.383 | 2.61E-04 | 1.21 | 1.09 | 1.33 | 5.62E-02 | 1.15 | 1.00 | 1.33 | 9.24E-06 | 1.51 | 1.26 | 1.80 | 9.24E-06 | LOC730242 | −206271 |
| 13 | rs1585440 | 65379816 | C | 0.761 | 0.713 | 9.28E-06 | 1.30 | 1.16 | 1.45 | 3.09E-05 | 1.35 | 1.17 | 1.55 | 7.36E-03 | 1.50 | 1.12 | 2.03 | 9.28E-06 | LOC387933 | −118820 |
| 3 | rs4683235 | 46476935 | A | 0.215 | 0.173 | 9.93E-06 | 1.31 | 1.16 | 1.48 | 7.53E-05 | 1.34 | 1.16 | 1.54 | 2.24E-03 | 1.70 | 1.21 | 2.38 | 9.93E-06 | LTF | 0 |
Odds ratios, 95% confidence limits and P-values were obtained using logistic regression analysis according to allelic, dominant and recessive model after adjustment of age, sex and smoking.
RAF, risk allele frequency; OR, odds ratio; L95, U95, lower and upper confidence limits; P min, minimum P-value among three genetic models.
*Position and relative loci (Relativeloc) are based on NCBI Human Genome Build 36.