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. Author manuscript; available in PMC: 2011 Aug 30.
Published in final edited form as: Int J Pharm. 2010 Jul 1;396(1-2):111–118. doi: 10.1016/j.ijpharm.2010.06.039

Table 1.

Structure and NMR results of CDCA-lysine-niacin and CDCA-lysine-ketoprofen.

graphic file with name nihms217793u1.jpg
Conjugate R1 1H-NMR (DMSO-d6)a
CDCA-lysine-niacin graphic file with name nihms217793t1.jpg 11.95 (1H, s, γ), 8.99 (1H, s, α), 8.69 (1H, d, α), 8.64 (1H, t, β), 8.17 (1H, d, α), 7.92 (1H, d, β), 7.48 (1H, t, α), 4.30 (1H, m, θ),
CDCA-lysine-ketoprofen graphic file with name nihms217793t2.jpgO 11.65 (1H, s, γ), 7.98 (1H, d, β) 8.04 (4, t, β) 7.78-7.58 (9H, α), 4.13(1H, m, γ) 3.68 (1H, m, α), 1.37 (3H, s, α)
a

Only characteristic peaks are shown. CDCA and methylene peaks are not shown.

Values are in ppm relative to TMS. α indicates assignment to proton peaks in R1; β indicates assignment to protons in amide; γ indicates assignment to protons in carboxylic acid region; θ indicates the proton in α carbon.