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. 2010 Jul 29;5(7):e11847. doi: 10.1371/journal.pone.0011847

Figure 8. The mouse NNK-ADC expression signature effectively separates both mouse and human lung adenocarcinomas from their adjacent normal counterparts.

Figure 8

A. Dendogram (left) of hierarchical cluster analysis and PCA (right) of the gene features (n = 1452) of the NNK-ADC signature that are present in the Affymetrix MG-U74Av2 platform and gene expression data of mouse normal lung (n = 15) and adenocarcinoma (n = 29) tissue from the study by Stearman et al [30]. Dendograms (left) of hierarchical cluster analysis and PCA (right) of human datasets including 20 lung adenocarcinomas and 19 adjacent normal lung samples from the study by Stearman et al (B) and 27 lung adenocarcinomas and 27 paired adjacent normal lung from the study by Su et al [29] (C) and using only orthologous genes of the signature and found in the Affymetrix MG-U95Av2 (B, n = 1877) and HG-U133A (C, n = 2475) platforms.