Table 2.
Univariate and Multivariate Analysis of 36-gene Signature and Usual Pronostic Factors in Relation to DFS
| Predictive Factors | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| Odds Ratio | 95% CI | P | Odds Ratio | 95% CI | P | |
| A - Training set (132 patients) | ||||||
| 36-gene signature: RF v. R | 14.61 | 6.07 to 35.19 | 6.3 · 10−11 | 17.89 | 5.62 to 56.94 | 1.05 · 10−6 |
| SBR Grade: I/II v. III | 4.60 | 1.87 to 11.27 | 0.0008 | 1.46 | 0.37 to 5.74 | 0.59 |
| Tumor size: < 20mm v. ≥ 20mm | 1.99 | 0.86 to 4.57 | 0.11 | - | - | - |
| PR: ≥ 20 fmol/mg v. <20 fmol/mg | 3.68 | 1.49 to 9.07 | 0.005 | 2.73 | 0.68 to 10.91 | 0.16 |
| Age: ≥ 55 years v. <55 years | 1.87 | 0.57 to 6.10 | 0.31 | - | - | - |
| ER: ≥ 20 fmol/mg v. < 20 fmol/mg | 1.07 | 0.26 to 4.51 | 0.95 | - | - | - |
| Node status: pN0 v. pN+ | 4.58 | 2.03 to 10.33 | 0.0001 | 3.05 | 0.75 to 12.45 | 0.12 |
| NPI: ≤ 3.4 v. > 3.4 | 7.16 | 2.33 to 22.04 | 0.0001 | 3.27 | 0.64 to 16.82 | 0.16 |
| Adjuvant !: < 20% v. ≥ 20% | 4.71 | 2.08 to 10.67 | 0.0002 | 1.22 | 0.31 to 4.76 | 0.78 |
| B- Validation set (83 patients) | ||||||
| 36-gene signature: RF v. R | 3.96 | 1.56 to 10.05 | 0.004 | 3.01 | 1.01 to 9.14 | 0.05 |
| SBR Grade: I/II v. III | 2.02 | 0.76 to 5.39 | 0.17 | - | - | - |
| Tumor size: < 20mm v. ≥ 20mm | 2.16 | 0.83 to 5.60 | 0.12 | - | - | - |
| PR: ≥ 20 fmol/mg v. <20 fmol/mg | 2.16 | 0.72 to 6.52 | 0.18 | - | - | - |
| Age: ≥ 55 years v. <55 years | 2.41 | 0.62 to 9.30 | 0.22 | - | - | - |
| ER: ≥ 20 fmol/mg v. < 20 fmol/mg | 4.65 | 0.46 to 46.69 | 0.21 | - | - | - |
| Node status: pN0 v. pN+ | 2.37 | 0.92 to 6.10 | 0.08 | - | - | - |
| NPI: ≤ 3.4 v. > 3.4 | 5.96 | 1.25 to 28.33 | 0.013 | 2.27 | 0.35 to 14.35 | 0.38 |
| Adjuvant !: < 20% v. ≥ 20% | 4.90 | 1.75 to 13.69 | 0.002 | 2.64 | 0.78 to 8.91 | 0.12 |
DFS, disease-free survival; RF, relapse-free; R, relapse; PR, progesterone receptor; ER, estrogen receptor; NPI, Nottingham prognostic index; v., versus; P, p value. Univariate and multivariate analyses were performed by logistic regression.
Multivariate analysis was performed using the parameters found to be significant in univariate analysis.