Table 3.
Comparison of the 36-gene signature with other molecular signatures
| Predictive Factors | Univariate Analysis in terms of DFS | ||
|---|---|---|---|
| Odds Ratio | 95% CI | P | |
| A - Training set (132 patients) | |||
| 36-gene signature | 14.61 | 6.07 to 35.12 | 6.4 · 10−11 |
| Intrinsic subtypes | 3.59 | 1.39 to 9.28 | 0.009 |
| 70-gene profile | 2.73 | 1.3 to 5.75 | 0.008 |
| Wound response | 1.91 | 0.93 to 3.95 | 0.08 |
| Two-gene ratio | 0.68 | 0.42 to 1.76 | 0.68 |
| GGI | 5.99 | 2.57 to 13.96 | 1.0 · 10−5 |
| MPI | 6.95 | 3.12 to 15.47 | 7.6 · 10−7 |
| B - Validation set (83 patients) | |||
| 36-gene signature | 3.96 | 1.56 to 10.05 | 0.004 |
| Intrinsic subtypes | 2.73 | 0.68 to 11.05 | 0.17 |
| 70-gene profile | 1.84 | 0.75 to 4.45 | 0.19 |
| Wound response | 2.46 | 1.01 to 6.03 | 0.05 |
| Two-gene ratio | 3.94 | 1.55 to 9.97 | 0.004 |
| GGI | 1.88 | 0.77 to 4.60 | 0.17 |
| MPI | 2.00 | 0.83 to 4.82 | 0.13 |
Univariate analysis was performed using logistic regression (RF v. R); DFS, disease-free survival; RF, relapse-free patients; R, patients with relapse.