Table 2.
Growth characteristics of the gene deletion library members screened for survival after induced expression of ER–targeted RTA
| Gene deletion |
Growth advantage (fold)a | |
|---|---|---|
| Standard name | Systematic name | |
| Dislocation complex proteins | ||
| CUE1 | YMR264W | 10–100 |
| UBC7 | YMR022W | 10–100 |
| HRD1 | YOL013C | ∼1000 |
| DOA10 | YIL030C | nme |
| HRD3 | YLR207W | ∼1000 |
| USA1 | YML029W | ∼100 |
| DER1 | YBR201W | ∼1000 |
| ER-Golgi transport | ||
| ERP1 | YAR002C-A | nme |
| ERP2 | YAL007C | 10,000 |
| ERP3 | YDL018C | nme |
| ERP4 | YOR016C | nme |
| ERP5 | YHR110W | nme |
| ERP6 | YGL002W | nme |
| EMP24 | YGL200C | nme |
| ERV25 | YML012W | nme |
| ERV29 | YGR284C | nme |
| ERV41 | YML067C | nme |
| ERV46 | YAL042W | nme |
| ERV14 | YGL054C | nme |
| EMP46 | YLR080W | nme |
| EMP47 | YFL048C | nme |
| ER luminal chaperones | ||
| YOS9 | YDR057W | nme |
| MNL1 | YHR204W | nme |
| JEM1 | YJL073W | nme |
| CNE1 | YAL058W | nme |
| Cytosolic chaperones and cochaperones | ||
| HLJ1 | YMR161W | nme |
| ZUO1 | YGR285C | nme |
| APJ1 | YNL077W | nme |
| YDJ1 | YNL064C | nme |
| SSA1 | YAL005C | nme |
| SSA2 | YLL024C | nme |
| SSA3 | YBL075C | nme |
| SSZ1 | YHR064C | nme |
| SSE1 | YPL106C | nme |
| SNL1 | YIL016W | nme |
| STI1 | YOR027W | nme |
| HSC82 | YMR186W | nme |
| HSP82 | YPL240C | nme |
| CPR6 | YLR216C | nme |
| CPR7 | YJR032W | nme |
| SBA1 | YKL117W | nme |
| AHA1 | YDR214W | nme |
| HCH1 | YNL281W | nme |
| Proteasome and associated proteins | ||
| UBR1 | YGR184C | nme |
| RPN10 | YHR200W | nme |
| SEM1 | YDR363W-A | nme |
| UBP6 | YFR010W | nme |
| UMP1 | YBR173C | nme |
| PNG1 | YPL096W | nme |
| RAD23 | YEL037C | nme |
| RAD4 | YER162C | nme |
| DSK2 | YMR276W | nme |
| Cdc48p and its binding proteins | ||
| NPL4 | YBR170C | nme |
| DOA1 | YKL213C | nme |
| OTU1 | YFL044C | nme |
| SHP1 | YBL058W | nme |
| UBX2 | YML013W | ∼10 |
| Signal peptidase complex | ||
| SPC1 | YJR010C-A | nme |
| SPC2 | YML055W | nme |
a nme, no measurable effect.