Table 3.

CSF-1–stimulated motility of BMMs

	Wild type	S100A4−/−	p value
Total path length (μm)	28.63 ± 1.67a	29.65 ± 1.93	N.S.b
Net path length (μm)	19.11 ± 1.70	11.73 ± 2.02	0.009
Directionality (net/total distance)	0.66 ± 0.04	0.40 ± 0.06	0.002
Velocity (μm/min)	1.43 ± 0.08	1.48 ± 0.10	N.S.
Direction change (°)	14.66 ± 2.79	40.91 ± 10.69	0.027
Chemotactic index (cos θ)	0.95 ± 0.02	0.66 ± 0.14	0.052

^a Values represent the mean ± SEM for 18 wild-type and 19 S100A4^−/− BMMs. Chemotaxis towards a point source of CSF-1 was monitored over 30 min.

^b N.S. represents p > 0.05.