Figure 5.

PKC activation is partially involved in UTP activation of CFTR. (A) GF109203X (2 μM), a PKC-specific inhibitor, was added to the luminal and basolateral solutions for 30 min before measurements (gray line). (B) Go6983 (1 μM), a nonselective PKC inhibitor, was added to luminal and basolateral solutions for 30 min before measurements (gray line). CFTR-dependent Isc are summarized in the bar graphs (error bars, SE; n = 3–5).