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. 2010 Jul 29;6(7):e1001026. doi: 10.1371/journal.ppat.1001026

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Dorer et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. The comB4 merodiploid (comB4^IE) induces expression of DNA damage responsive genes. Untreated wild-type cells are compared to either wild-type cells treated with ciprofloxacin (WT+C) or untreated comB4^IE cells and the mean of fold change in RNA expression measured by microarray from three independent cultures is shown. Bottom, scale bar indicates fold change for heat maps in A,B,C. B. Increased expression of DNA damage responsive genes in comB4^IE cells requires recA and the com T4SS. Untreated wild-type cells are compared to either comB4^IE ΔcomB10 (comB4^IE B10) cells, or comB4^IE ΔrecA cells and data is represented as in Figure 1A. C. Full induction of DNA damage responsive genes by DNA damage requires the com T4SS. Untreated wild-type cells are compared to ciprofloxacin treated ΔcomB10 mutant cells (B10- +C) and untreated ΔaddA ΔcomB10 double mutant cells (B10- addA-). Data is represented as in Figure 1A.