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. Author manuscript; available in PMC: 2011 Jul 27.
Published in final edited form as: Biochemistry. 2010 Jul 27;49(29):5978–5988. doi: 10.1021/bi1004359

Figure 6.

Figure 6

A thermodynamic cycle for the various equilibria linked to the binding of ERα to DNA. (a) ERα becomes protonated in the free form and the resulting protonated form (P) binds to DNA. (b) ERα binds to DNA in the unprotonated form (U) and the resulting liganded form becomes protonated.