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. Author manuscript; available in PMC: 2011 Jul 27.
Published in final edited form as: Biochemistry. 2010 Jul 27;49(29):5978–5988. doi: 10.1021/bi1004359

Figure 8.

Figure 8

Amino acid sequence alignment of DB domains of all known members of human NR family. Absolutely conserved residues are shown in red, while all other residues are depicted in black. Each member is denoted by its acronym in the left column with the corresponding Expasy code provided in the right column for access to complete proteomic details on each member. The numerals hyphenated to amino acid sequence at each end denote the boundaries of DB domains for each member. The cysteine residues within each of the two Zinc fingers of DB domains, denoted ZF-I and ZF-II, that coordinate the Zn2+ ion in a tetrahedral arrangement are marked by asterisks. Residues D190, H196, E203 and K206, located within the DB domain of ERα, are indicated by vertical arrows.