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. Author manuscript; available in PMC: 2011 Jul 21.
Published in final edited form as: Bioconjug Chem. 2010 Jul 21;21(7):1190–1205. doi: 10.1021/bc900569u

Scheme 1.

Scheme 1

Synthesis of C2 derivatives of P2Y1 receptor antagonists containing terminal ester 5–7, carboxylic acid 8–10, and amino 11–16 groups. Reagents and conditions: (i) CuI, (Ph3P)2PdCl2,TEA, DMF, rt; (ii) TFA, CH2Cl2, rt; (iii) ethylenediamine, MeOH, rt; (iv) KOH, H2O, rt; (v) TFA, CH2Cl2, rt.