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Preparation of biotin derivatives of a P2Y1 receptor antagonist for avidin complexation. Reagents and conditions: (i) biotin, DIEA, HATU, DMF, rt; (ii) biotinamidohexanoic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt, bicarbonate buffer, DMF, rt; (iii) TFA, CH2Cl2.
