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. Author manuscript; available in PMC: 2011 Jul 21.
Published in final edited form as: Bioconjug Chem. 2010 Jul 21;21(7):1190–1205. doi: 10.1021/bc900569u

Scheme 4.

Scheme 4

Use of click chemistry to couple P2Y1 antagonists to small azido-bearing molecules AcNH(CH2)2 present in the final products 2023 is a group to serve as a model for the attachment to a PAMAM dendrimer. Reagents and conditions: (i) diyne, CuI, (Ph3P)2PdCl2,TEA, DMF, rt; (ii) AcNHCH2CH2N3, CuSO4 aq., sodium ascorbate; (iii) TFA.