Use of click chemistry to couple P2Y1 antagonists to small azido-bearing molecules AcNH(CH2)2 present in the final products 20–23 is a group to serve as a model for the attachment to a PAMAM dendrimer. Reagents and conditions: (i) diyne, CuI, (Ph3P)2PdCl2,TEA, DMF, rt; (ii) AcNHCH2CH2N3, CuSO4 aq., sodium ascorbate; (iii) TFA.