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. Author manuscript; available in PMC: 2011 Jul 28.
Published in final edited form as: J Am Chem Soc. 2010 Jul 28;132(29):9940–9943. doi: 10.1021/ja103781u

Figure 1.

Figure 1

Schemes for (A) SHAPE chemistry and (B) RNase R recognition and degradation of RNA. 2′-hydroxyl and nucleobase positions specifically recognized in the active site cleft are shown as a red sphere and in blue, respectively. Phosphate hydrolysis occurs at the green sphere; an active site Mg2+ is yellow and other phosphate groups are gray.