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. Author manuscript; available in PMC: 2011 Jul 21.
Published in final edited form as: J Am Chem Soc. 2010 Jul 21;132(28):9820–9825. doi: 10.1021/ja103010b

Scheme 2.

Scheme 2

A simplified kinetic scheme for of wild-type E. coli TSase (revised from Ref 34). A represents dUMP and B CH2H4folate. The only isotopically sensitive step here is represented by the rate constant k5.