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Top: Amino acid sequences, molecular weight and structures of synthesized fluorescent exendin-4 based compounds. Bottom Left: The molecular model of exendin-4-like NIR fluorochrome, E4K12-Fl, is based on the nuclear magnetic resonance (NMR)-structure, 1JRJ (33). Bottom right: The molecular model of exendin-4-like NIR fluorochrome E4K12-Fl (amino acids 9–39) complexed with the extracellular domain of GLP-1R, is based on the crystal structure, 3C59 (30).
