Table 4.

Association of Lp(a) with Prevalent Type 2 Diabetes in the Copenhagen City Heart Study (Nonfasting Samples)

		Quintile 1	Quintile 2	Quintile 3	Quintile 4	Quintile 5	P for Trend	PInteraction for sex
Range, mg/dL
Women	N=5,441	<4.4	4.4–13.0	13.1–25.5	25.6–54.0	>54.0
Men	N=4,211	<3.3	3.3–10.5	10.6–22.7	22.8–46.4	>46.4
All	N=9,652	<3.9	3.9–11.7	11.8–24.1	24.2–49.8	>49.8
Model 1, OR (95% CI)
Women		Ref.	0.69(0.41–1.17)	0.97(0.61–1.55)	0.75(0.46–1.23)	0.94(0.59–1.50)	0.90
Men		Ref.	0.65(0.44–0.94)	0.43(0.28–0.66)	0.65(0.45–0.94)	0.49(0.33–0.74)	0.001	0.16
All		Ref.	0.65(0.48–0.88)	0.59(0.44–0.81)	0.68(0.50–0.91)	0.63(0.46–0.85)	0.005
Model 2, OR (95% CI)
Women		Ref.	0.71(0.42–1.20)	0.89(0.55–1.44)	0.74(0.45–1.22)	0.87(0.54–1.40)	0.64
Men		Ref.	0.67(0.46–0.99)	0.43(0.28–0.65)	0.66(0.45–0.97)	0.53(0.35–0.80)	0.003	0.38
All		Ref.	0.66(0.48–0.90)	0.57(0.42–0.78)	0.68(0.50–0.92)	0.63(0.46–0.86)	0.007
Model 3, OR (95% CI)
Women		Ref.	0.89(0.51–1.54)	1.03(0.62–1.71)	0.94(0.55–1.59)	0.85(0.51–1.41)	0.61
Men		Ref.	0.75(0.51–1.12)	0.48(0.31–0.75)	0.70(0.47–1.04)	0.49(0.32–0.74)	0.001	0.28
All		Ref.	0.75(0.55–1.03)	0.64(0.46–0.88)	0.74(0.54–1.01)	0.58(0.42–0.79)	0.002

Quintiles were defined based on the distribution among women not taking hormone replacement, among men, or among the entire cohort, respectively.

P for trend for odds ratios (OR) were obtained from logistic regression models using quintile number as predictor.

P for interaction with sex was obtained from likelihood ratio tests for interaction with sex and the Lp(a) concentration as a continuous variable, in relation to prevalent type 2 diabetes.

Model 1: Adjusted for age and sex.

Model 2: Adjusted for model 1 variable plus smoking status, menopausal status (women only), postmenopausal hormone use (women only), family history of diabetes, hypertension, and body mass index.

Model 3: Adjusted for model 2 variables plus hsCRP, LDL cholesterol (corrected for the Lp[a] contribution(14)), HDL cholesterol, and triglycerides.