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IQGAP1 regulates HepG2 cells proliferation through the PI3K/Akt pathway. (A) equal numbers of HepG2 cells were stably transfected with pcDNA3 vector (HepG2/V), Myc-tagged IQGAP1 (HepG2/I), IQGAP1ΔGRD (ΔGRD) or IQGAP1-sih (HepG2-sih) and analyzed by Western blot. (B) proliferation of HepG2/V cells, HepG2/I cells, or cells incubated with 50 µM PI3K inhibitor LY294002 (LY).
