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. Author manuscript; available in PMC: 2011 Jan 15.
Published in final edited form as: Cancer Res. 2010 Jul 7;70(14):5963–5973. doi: 10.1158/0008-5472.CAN-10-1028

Fig. 1. Primary screen.

Fig. 1

a. pathway activators (see text) that were used to induce Wnt/β-catenin signaling at distinct levels. b. the reporter construct used in the human epithelial HEK293-based cell line. The bicistronic TCF-luciferase-IRES-GFP reporter contained the Wnt response element from the Xnr3 promoter and four TCF binding sites. c. fold induction, coefficients of variation, and Z'-factors following 24 h estradiol and lithium induction. d. subset of thirteen 384-well plates (alternate shades of gray) and DMSO control plates (black) from the primary screen data. The dotted line indicates 50% inhibition of estradiol induction.