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a. Compound attrition flow diagram leading to selected hits. b. Structures of the three hit compounds CCT031374, CCT036477 and CCT070535. c. Summary of the effects of 30μM CCT031374, CCT036477 and CCT070535 on TCF-dependent transcription induced at different levels of the Wnt pathway. Control Gal4-luciferase reporter activity was induced by VP16-Gal4.
