Table 3.
Stool sample PCR (+) (N = 11) |
Stool sample PCR (−) (N = 17) |
Odds ratio | P value | |
---|---|---|---|---|
Samples from children with positive tuberculin skin test | 8 | 17 | 0 95% confidence interval [0–0.71] |
0.03 |
Sample from children with cough for > 2 weeks | 8 | 4 | 8.6 | 0.01 |
Paired gastric aspirate culture positive | 10 | 10 | 7 | 0.066 |
Stool sample auramine microscopy positive | 3 | 0 | > 1,000* | 0.02 |
At least one paired culture-positive specimen (gastric aspirate, nasopharyngeal aspirate, or stool) | 11 | 10 | > 1,000* | 0.01 |
Logistic regression of factors associated with a positive PCR result among 28 stool samples from 16 children with culture-proven pulmonary tuberculosis.
The following factors were also studied but did not approach statistical significance: age (older than 5 years), OR = 1.2, P = 0.8; male sex, Odds ratio (OR) = 1.9, P = 0.5; Stegen Toledo score > 7, OR = 1.45, P = 0.7; suspect radiograph, OR = 0.31, P = 0.3; pulmonary infiltrate on radiograph, OR = 6, P = 0.1; contact with adult tuberculosis patient, OR = 0.6, P = 0.6; nasopharyngeal aspirate auramine microscopy positive, OR = 2.5, P = 0.3; gastric aspirate auramine microscopy positive, OR = 6, P = 0.1; stool culture positive, OR = 3.5, P = 0.3.
Because all stool samples with paired culture-positive gastric aspirate samples were PCR positive and no stool sample that was auramine microscopy positive was stool PCR negative, the odds ratios for these factors approached infinity and therefore cannot be exactly calculated.