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Quantification of iron oxide microparticles (MPIOs) under venous and arterial flow conditions. At venous flow, a constant increase in ligand-induced binding site (LIBS)-MPIO binding 2 minutes after flow initiation can be observed with only modest background binding for control MPIO. After switching from venous to arterial flow, MPIO binding remained almost constant, without a significant wash-off effect, after 1 minute of arterial flow.
