Table 5.
Treatment | Days with asexual parasites | Days with gametocytes | ||
---|---|---|---|---|
Mean (95% CI)*† | Mean (95% CI)‡ | Mean (95% CI)† | Mean (95% CI)‡ | |
CQ and SP | 4 (2–6)a | 2.4 (1.5–3.3) | 19 (18–20)a | 18.1 (16.7–19.5) |
AQ and SP | 2 (1–2)a | 1.8 (1.4–2.2) | 14 (13–16)a | 13.6 (11.8–15.4) |
MQ and SP | 2 (1–3)a | 1.8 (1.2–2.4) | 11 (9–14)a | 10.4 (8.3–12.5) |
AS and SP | 1 (1–1)b | 0.9 (0.9–1.0) | 5 (3–7)b | 3.7 (2.2–5.2) |
AS and AQ | 1 (1–1)c | 0.7 (0.6–0.8) | 2 (1–4)cd | 2.1 (0.5–3.7) |
AS and MQ | 1 (0–1)cd | 0.5 (0.3–0.8) | 2 (0–3)d | 1.6 (0.0–3.2) |
AS, MQ, and PQ | 0 (0–1)d | 0.4 (0.2–0.6) | 1 (0–1)de | 0.6 (0.0–1.4) |
Breslow statistic = 203.91, P = 0.00001 | Breslow statistic 173.64, P = 0.00001 |
CI = confidence interval; CQ = chloroquine; SP = sulfadoxine-pyrimethamine; AQ = amodiaquine; MQ = mefloquine; AS = artesunate; PQ = primaquine. Superscript letters that are not repeated among the treatments show statistically significant differences by the log-rank test or Breslov test.
Parasite mean survival time obtained by using Kaplan-Meier analysis.
Arithmetic mean in days taken for parasites to disappear.