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. Author manuscript; available in PMC: 2010 Jul 30.
Published in final edited form as: Tetrahedron Lett. 2009 Mar 25;50(12):1264–1266. doi: 10.1016/j.tetlet.2008.12.114

Table 2.

Synthesis of γ-bromo ketones15

graphic file with name nihms213708t2.jpg
Substrate Product R R′ Yield (%)
1a 3a Ph H 87a
1b 3b p-CH3O-Ph H 70a
1c 3c p-F-Ph H 95a
1d 3d Cyclohexyl H NDb
1e 3e n-hexyl H NDb
1f 3f p-F-Ph Et 37c
a

Isolated yield.

b

Mixture of 1-alkyl-cyclobutanol, γ-bromo ketone and α,γ-dibrominated ketones.

c

Determined by 1H NMR.