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. Author manuscript; available in PMC: 2010 Jul 30.
Published in final edited form as: Tetrahedron Lett. 2009 Mar 25;50(12):1264–1266. doi: 10.1016/j.tetlet.2008.12.114

Table 3.

α-Bromination of aliphatic substrates

graphic file with name nihms213708t3.jpg
Entry Conditionsa Ratio (5:4)b
1 4 (0.33 mmol), Br2 (0.17 mmol) 3:1
2 4 (0.33 mmol), KBr (0.33 mmol), CAN (0.66 mmol) 3:1
3 4 (0.33 mmol), KBr (0.33 mmol), CAN (0.83 mmol) 9:1
a

50% H2O/CH2Cl2.

b

Ratios determined by GC.