Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Jul 29;6(7):e1001025. doi: 10.1371/journal.ppat.1001025

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Saini et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

(A) Effect of positive feedback on HilD expression. Plot shows steady-state concentration of HilD as a function of the parameters and . The parameter specifies the degree by which the SPI1 regulators - HilC, HilD, and RtsA - can activate HilD expression, effectively the strength of positive feedback on HilD expression. The parameter specifies the strength of the signal activating HilD expression. (B) Effect of HilC and RtsA on HilD expression. Plot shows the steady-state concentration of HilD as a function of the parameters , , and . The parameters and specify the degree by which the SPI1 regulators - HilC, HilD, and RtsA - can activate HilC and RtsA expression, respectively. In other words, these parameters set the strength of feedback on HilC and RtsA expression. In these simulations, the parameters and were both varied in tandem: the numerical values for the two are the same. (C) Effect of HilE on HilD expression. Plot shows the steady-state concentration of HilD as a function of the parameters and . The parameter specifies the rate of HilE expression. Results for HilA are shown in Figures S6A–C. The black lines in the plots are used to denote the results obtained using the nominal parameters (aside from ). A detailed description of the model is provided in the Materials and Methods.

Inline graphic — (A) Effect of positive feedback on HilD expression. Plot shows steady-state concentration of HilD as a function of the parameters and . The parameter specifies the degree by which the SPI1 regulators - HilC, HilD, and RtsA - can activate HilD expression, effectively the strength of positive feedback on HilD expression. The parameter specifies the strength of the signal activating HilD expression. (B) Effect of HilC and RtsA on HilD expression. Plot shows the steady-state concentration of HilD as a function of the parameters , , and . The parameters and specify the degree by which the SPI1 regulators - HilC, HilD, and RtsA - can activate HilC and RtsA expression, respectively. In other words, these parameters set the strength of feedback on HilC and RtsA expression. In these simulations, the parameters and were both varied in tandem: the numerical values for the two are the same. (C) Effect of HilE on HilD expression. Plot shows the steady-state concentration of HilD as a function of the parameters and . The parameter specifies the rate of HilE expression. Results for HilA are shown in Figures S6A–C. The black lines in the plots are used to denote the results obtained using the nominal parameters (aside from ). A detailed description of the model is provided in the Materials and Methods.