Table 2.

Reversal performance and forebrain NE depletion after DSP-4 treatment in C57BL/6J mice

	Vehicle	DSP-4
Reversal performance
Total trials	171 ± 5	157 ± 8
Total errors	94 ± 4	90 ± 4
Total correction errors	364 ± 34	400 ± 34
Perseveration index	3.7 ± 0.4	4.7 ± 0.6
Total trials omitted	9.2 ± 5.0	23.5 ± 7.8
Average stimulus reaction time (s)	3.8 ± 0.4	4.3 ± 0.5
Average reward retrieval latency (s)	2.0 ± 0.1	2.1 ± 0.2
NE tissue content
mPFC (ng/g)	395.4 ± 68.5	222.9 ± 30.3 (−43.6%)*
Hippocampus (ng/g)	412.3 ± 35.3	238.0 ± 33.0 (−42.3%)*
5-HT tissue content
mPFC (ng/g)	397.8 ± 46.4	397.8 ± 73.6 (−5.9%)
Hippocampus (ng/g)	448.6 ± 55.2	423.8 ± 30.1 (−4.6%)

DSP-4 treatment did not significantly affect any measure of reversal performance, despite significantly reducing tissue content of NE (but not 5-HT) in the mPFC and hippocampus. n = 10 per treatment. Data are means ± standard errors of the mean.

*P < 0.05 versus vehicle.