Figure 5.

Salience Network disruption and DMN enhancement correlate with bvFTD clinical severity. In bvFTD, CDR, sum of boxes scores (CDR-SB) showed a significant (A) negative correlation with Salience Network connectivity in right frontoinsula (FI) and (B) positive correlation with DMN connectivity in bilateral angular gyrus (ANG), as well as ventromedial prefrontal cortex (vmPFC) and right intraparietal sulcus (R IPS, not shown). Results are atrophy corrected and thresholded at a joint height and extent probability of P < 0.05, corrected at the whole brain level. Colour bars represent t-scores, and statistical maps are superimposed on the Montreal Neurological Institute template brain.