Table 1.
Demographic and disease features at baseline in 3 cohorts
| VARIABLES | COHORTS | P VALUES* | ||
|---|---|---|---|---|
| 1 | 2 | 3 | ||
| Age (years) | 59 ± 2 | 64 ± 4 | 65 ± 2 | 0.28 |
| Gender F/M | 9/0 (100%) | 5/3 (62.5%) | 16/7 (70%) | 0.133 |
| Non-Hispanic Caucasian | 67% | 75% | 91% | 0.21 |
| BMI | 35.3 ± 4.6 | 30.4 ± 1.6 | 29.6 ± 1.2 | 0.20 |
| Knee/Hip | 8/1 | 5/3 | 20/3 | 0.60 |
| Walking Time (sec) | 12.0 ± 2.6 | 7.3 ± 0.7 | 7.7 ± 0.4 | 0.009 |
| WOMAC Item #1 | 3.2 ± 0.3 | 2.4 ± 0.3 | 3.9 ± 0.4 | 0.075 |
| WOMAC Item #5 | 3.2 ± 0.3 | 2.4 ± 0.3 | 2.4 ± 0.2 | 0.047 |
| BPI ** | 5.6 ± 0.9 | 2.6 ± 0.7 | 3.9 ± 0.4 | 0.19 |
| Global VAS (mm) | 54.5 ± 10.9 | 31.0 ± 6.7 | 45.8 ± 4.4 | 0.15 |
| Modified HAQ (0-3 scale) | 1.4 ± 0.2 | 0.7 ± 0.1 | 0.8 ± 0.1 | 0.17 |
| Hemoglobin (g/dL)† | 13.0 ± 0.5 | 14.2 ± 0.4 | 14.4 ± 0.2 | 0.016 |
| Creatinine (mg/dL)† | 0.77 ± 0.06 | 0.80 ± 0.09 | 0.82 ± 0.03 | 0.74 |
| AST (U/L)† | 19 ± 1 | 23 ± 2 | 24 ± 2 | 0.32 |
*P values for Age and BMI calculated with one-way ANOVA or Fisher's Exact Test.
**BPI Score is mean for items 3-6 and 9(A-G).
† Normal ranges: Hemoglobin 13.2-16.2 g/dL; creatinine 0.7-1.2 mg/dL; AST 13-40 U/L.