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Table 1.

Incidence and size of dysplasia

WT TLR4-/- PBS PGE 2 high dose PGE 2 low dose
(n = 13) (n = 7) (n = 8) (n = 6)
Incidence (%) 92.3 28.6 75 33.3
Tumors/animal
(range)
3.1 ± 1.1
(1 - 15)
0.4 ± 0.2
(0 - 2)
1.5 ± 1.2*
(0 - 3)
0.3 ± 0.5
(0 - 1)
Tumor size (mm)
(range)
3.3 ± 2.1
(1 - 8)
0.4 ± 0.8
(0.5 - 1)
1.8 ± 1.3*
(1 - 4)
0.8 ± 1.1
(2 - 2)
Percentage of mucosal surface with tumor
(range)
17.4% ± 13.8
(0 - 40)
1.4% ± 2.4
(0 - 5)
6.3% ± 4.4*
(0 - 10)
1.5% ± 0.4
(0 - 3)

* P < 0.05, compared to corresponding result in PBS treated control mice.

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