Table 1.
Incidence and size of dysplasia
| WT | TLR4-/- PBS | PGE 2 high dose | PGE 2 low dose | |
|---|---|---|---|---|
| (n = 13) | (n = 7) | (n = 8) | (n = 6) | |
| Incidence (%) | 92.3 | 28.6 | 75 | 33.3 |
| Tumors/animal (range) |
3.1 ± 1.1 (1 - 15) |
0.4 ± 0.2 (0 - 2) |
1.5 ± 1.2* (0 - 3) |
0.3 ± 0.5 (0 - 1) |
| Tumor size (mm) (range) |
3.3 ± 2.1 (1 - 8) |
0.4 ± 0.8 (0.5 - 1) |
1.8 ± 1.3* (1 - 4) |
0.8 ± 1.1 (2 - 2) |
| Percentage of mucosal surface with tumor (range) |
17.4% ± 13.8 (0 - 40) |
1.4% ± 2.4 (0 - 5) |
6.3% ± 4.4* (0 - 10) |
1.5% ± 0.4 (0 - 3) |
* P < 0.05, compared to corresponding result in PBS treated control mice.