Table 3.
Muscle-capillary interface parameters for type I and type IIa fibres.
|
Healthy subjects (n = 12) |
Mild COPD (n = 8) |
Moderate COPD (n = 9) |
Severe COPD (n = 6) |
p value | |
|---|---|---|---|---|---|
| C:Fi type I | 2.7 ± 0.5 | 2.7 ± 1.3 | 2.0 ± 0.4* | 2.0 ± 0.5* | 0.007 |
| C:Fi type IIa | 2.5 ± 0.5 | 2.5 ± 1.1 | 1.6 ± 0.4* | 1.7 ± 0.4 | 0.002 |
| CFPE type I | 8.3 ± 1.1 | 8.1 ± 3.0 | 6.8 ± 0.9* | 6.2 ± 0.6 * | 0.002 |
| CFPE type IIa | 6.6 ± 0.9 | 7.3 ± 2.6 | 5.9 ± 0.8 | 5.8 ± 1.1 | ns |
| LC type I | 72.4 ± 8.4 | 77.0 ± 25.0 | 58.8 ± 14.6 | 67.4 ± 29.0 | ns |
| LC type IIa | 64.8 ± 19.5 | 64.7 ± 17.8 | 45.2 ± 10.6 | 57.4 ± 25.8* | 0.03 |
| LC/PF type I | 21.8 ± 1.4 | 22.3 ± 5.6 | 20.0 ± 4.7 | 20.4 ±4.1 | ns |
| LC/PF type IIa | 17.5 ± 2.5 | 19.0 ± 4.1 | 16.3 ± 2.2 | 18.2 ± 2.5 | ns |
Data are presented as mean ± SD.
*Significantly lower compared to healthy subjects.
n = number of test subjects; C:Fi = the sum of the fractional contributions of all capillary contacts around the fibre, i.e. the individual capillary-to-fibre ratio; CFPE = quotient between C:Fi and the fibre perimeter; LC = length of capillaries in contact with muscle fibre; LC/PF = ratio between LC and fibre perimeter; ns = not significant.