Table 3.
Subanalysis in IDC cases: immunohistochemical variables
| Univariable analysis | |||
|---|---|---|---|
| Variables | N (%) | Hsp90 Allred score | p |
| Triple-negative status§ | 0.0004MWW | ||
| Triple-negative | 9 (17.7%) | 6.44 ± 1.01 | |
| Non-triple-negative | 42 (82.3%) | 7.52 ± 0.55 | |
| ER Allred score† | 0.004S | ||
| < median | 23 (45.1%) | 7.04 ± 0.93 | |
| ≥median | 28 (54.9%) | 7.57 ± 0.50 | |
| PR Allred score† | 0.020S | ||
| < median | 21 (41.2%) | 6.95 ± 0.86 | |
| ≥median | 30 (58.8%) | 7.60 ± 0.56 | |
| c-erbB-2 status | 0.011MWW | ||
| Negative | 29 (56.9%) | 7.10 ± 0.86 | |
| Positive | 22 (43.1%) | 7.64 ± 0.49 | |
| Multivariable analysis | |||
| Variables | Category or increment | OR (95% CI) | p |
| ER Allred score | 1 point increase‡ | 1.29 (0.99-1.66) | 0.055 |
| PR Allred score | 1 point increase | 1.18 (0.92-1.51) | 0.195 |
| c-erbB-2 status | Positive vs. negative | 1.85 (1.14-3.02) | 0.013 |
MWWp-value derived from Mann-Whitney-Wilcoxon test for independent samples; Sp-value derived from Spearman's rank correlation coefficient; § not included in the multivariable analysis, as it integrates all three components (ER, PR, c-erbB-2); †ER Allred score, PR Allred score have been treated as continuous variables and thus the subcategories serve purely descriptive purposes ‡practical interpretation: increase in Allred score by one unit predicts OR = 1.29.