Table 1.
Relation of MMP-3 genotype to clinical parameters and environmental factors among the OSMF, HNSCC and Control.
| Characteristics | OSMF (N = 101) |
HNSCC (N = 135) |
Total Control | Control (N = 126) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6A/6A genotype | 5A/6A genotype | 5A/5A genotype | p-value | 6A/6A genotype | 5A/6A genotype | 5A/5A genotype | p-value | 5A/5A genotype | 6A/6A genotype | 5A/6A genotype | (p-value) | |||
| Total | N = 236 | 74 (73.27%) |
24 (23.76%) |
3 (2.97%) |
106 (78.5%) |
23 (17.03%) |
6 (4.44%) |
126 | 2 (1.6%) |
110 (87.3%) |
14 (11.1%) |
|||
| Gender | ||||||||||||||
| Male | 192 (81.35) | 62(83.8) | 14(58.3) | 2(66.6) | 0.001 | 94 (88.67) | 15(65.21) | 5 (83.3) | 0.01 | 105(83.3) | 2 (100) | 101 (91.8) | 2(14.3) | 0.01 |
| Female | 44 (18.64) | 12(16.2) | 10 (41.6) | 1(33.3) | 12 (11.32) | 8(34.78) | 1 (16.6) | 21(16.7) | 0 | 9(8.2) | 12(85.7) | |||
| Age (Yrs) | ||||||||||||||
| Mean ± SD | 43.4 ± 14.8 | 38.8 ± 14.5 | 37.6 ± 14.2 | 36 ± 8.5 | 0.671 | 42 ± 16.5 | 47 ± 10.8 | 41 ± 9.86 | 0.42 | 37.0 ± 12.8 | 17.5 ± 0.7 | 36.7 ± 12.4 | 38.8 ± 16 | 0.41 |
| Tobacco with Areca nut | ||||||||||||||
| Chewer | 215(91.1) | 72(97.3) | 23 (95.8) | 2 (66.7) | 0.02 | 98(92.45) | 16(69.56) | 4 (66.6) | 0.003 | 85(67.5) | 2(100) | 71(64.5) | 12(85.7) | 0.12 |
| Non Chewer | 21(8.9) | 2(2.7) | 1 (4.2) | 1 (33.3) | 8(7.54) | 7(30.43) | 2 (33.3) | 41(32.5) | 0 | 39(35.5) | 2(14.3) | |||
| Smoking status | ||||||||||||||
| Smoker | 170(72.03) | 42(56.7) | 19(79.2) | 3 (100) | 0.077 | 88(83.01) | 15(65.21) | 4 (66.6) | 0.037 | 51(40.5) | 0 | 47(42.7) | 4(28.6) | 0.11 |
| Non-smoker | 66 (27.9) | 32(43.3) | 5 (20.8) | 0 | 18(16.98) | 8(34.78) | 2 (33.3) | 75(59.5) | 2(100) | 63(57.3) | 10(71.4) | |||
| Alcohol Intake | ||||||||||||||
| Drinker | 117(49.57) | 22(29.7) | 3 (12.5) | 2 (66.7) | 1.16 | 72(67.92) | 14(60.86) | 3 (50) | 0..81 | 26(20.6) | 0 | 25(22.7) | 1(7.1) | 0.24 |
| Non Drinker | 119(50.42) | 52(70.3) | 21 (87.5) | 1 (33.3) | 34(32.07) | 9(39.1) | 3 (50) | 100(79.4) | 2(100) | 85(77.3) | 13(92.9) | |||
| Location | ||||||||||||||
| Lip (lower &upper) | 51 (21.61) | 20(27) | 7 (29.2) | 1 (33.3) | 19(17.92) | 3(13.04) | 1(16.67) | |||||||
| Tongue | 38 (16.1) | 10(13.5) | 4 (16.7) | 0 | 21(19.81) | 2(8.69) | 1 (16.1) | |||||||
| Right & left Cheek | 32(13.56) | 11(15) | 3 (12.5) | 1 (33.3) | 0.81* | 14(13.20) | 3(13.04) | 1 (16.1) | 0.59* | - | - | - | - | - |
| Buccal mucosa | 34 (14.41) | 10(13.5) | 4 (16.6) | 0 | 15(14.15) | 3(13.04) | 1 (16.1) | |||||||
| Larynx/pharynx | 81 (34.32) | 23(31) | 6(25) | 1 (33.3) | 37(34.91) | 12(52.17) | 2 (33.3) | |||||||
| OSMF Grade | ||||||||||||||
| (N = 101) | ||||||||||||||
| I-II | 73 (72.28) | 55 (74.3) | 16 (66.6) | 2 (66.6) | 0.001 | - | - | - | - | - | - | - | - | |
| III-IV | 28 (27.72) | 19 (25.7) | 8 (33.3) | 1 (33.3) | ||||||||||
| HNSCC Grade | ||||||||||||||
| (N = 135) | ||||||||||||||
| T category | ||||||||||||||
| T1-3 | 37 (27.41) | 21 (19.81) | 14 (60.86) | 2 (33.3) | ||||||||||
| T4 | 98 (72.59) | - | - | - | - | 85 (80.18) | 9 (39.13) | 4 (66.6) | 0.001 | |||||
| N category | ||||||||||||||
| N0 | ||||||||||||||
| N1-3 | 42 (31.11) 93 (68.89) |
- | - | - | - | 30 (28.31) 76 (71.69) |
6 (26.1) 17 (73.9) |
1 (16.7) 5 (83.3) |
0.814 |
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T & N categories [UICC TNM classification], Fisher's exact test & * Pearson's χ2 test were applied for statistical analysis.